| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-IGF2BP2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
IGF2BP2 |
| Gene ID: |
10644 |
| Uniprot ID: |
IF2B2_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_006539.3; NP_001007226.1 |
| Specificity: |
This antibody is expected to recognise both reported isoforms (NP_006539.3 and NP_001007226.1). |
| Immunogen Sequence: |
KQQEQKYPQGVASQR |
| Function | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD. |
| Protein Name | Insulin-Like Growth Factor 2 Mrna-Binding Protein 2Igf2 Mrna-Binding Protein 2Imp-2Hepatocellular Carcinoma Autoantigen P62Igf-Ii Mrna-Binding Protein 2Vickz Family Member 2 |
| Database Links | Reactome: R-HSA-428359 |
| Cellular Localisation | NucleusCytoplasmP-BodyStress GranuleLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasLocalizes At The Connecting Piece And The Tail Of The SpermatozoaIn Response To Cellular StressSuch As Oxidative StressRecruited To Stress Granules |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor 2 Mrna-Binding Protein 2 antibodyAnti-Igf2 Mrna-Binding Protein 2 antibodyAnti-Imp-2 antibodyAnti-Hepatocellular Carcinoma Autoantigen P62 antibodyAnti-Igf-Ii Mrna-Binding Protein 2 antibodyAnti-Vickz Family Member 2 antibodyAnti-IGF2BP2 antibodyAnti-IMP2 antibodyAnti-VICKZ2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
