• STJ71433 (1µg/ml) staining of HepG2 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • HEK293 overexpressing IGF2BP2 (RC205673) and probed with STJ71433 (mock transfection in first lane) , tested by Origene.

Anti-IGF2BP2 antibody (C-Term) (STJ71433)

SKU:
STJ71433-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-IGF2BP2 (C-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: IGF2BP2
Gene ID: 10644
Uniprot ID: IF2B2_HUMAN
Immunogen Region: C-Term
Accession Number: NP_006539.3; NP_001007226.1
Specificity: This antibody is expected to recognise both reported isoforms (NP_006539.3 and NP_001007226.1).
Immunogen Sequence: KQQEQKYPQGVASQR
Function RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD.
Protein Name Insulin-Like Growth Factor 2 Mrna-Binding Protein 2
Igf2 Mrna-Binding Protein 2
Imp-2
Hepatocellular Carcinoma Autoantigen P62
Igf-Ii Mrna-Binding Protein 2
Vickz Family Member 2
Database Links Reactome: R-HSA-428359
Cellular Localisation Nucleus
Cytoplasm
P-Body
Stress Granule
Localized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas
Localizes At The Connecting Piece And The Tail Of The Spermatozoa
In Response To Cellular Stress
Such As Oxidative Stress
Recruited To Stress Granules
Alternative Antibody Names Anti-Insulin-Like Growth Factor 2 Mrna-Binding Protein 2 antibody
Anti-Igf2 Mrna-Binding Protein 2 antibody
Anti-Imp-2 antibody
Anti-Hepatocellular Carcinoma Autoantigen P62 antibody
Anti-Igf-Ii Mrna-Binding Protein 2 antibody
Anti-Vickz Family Member 2 antibody
Anti-IGF2BP2 antibody
Anti-IMP2 antibody
Anti-VICKZ2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance