| Host: | Goat |
| Applications: | Pep-ELISA/WB/IF |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-IFT88/Polaris (C-Term) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx. 80kDa band observed in lysates of cell lines THP-1, K562 and KNRK and 85kDa in lysates of cell line U251 (calculated MW of 94.3kDa according to Human NP_783195.2) and 93.1kDa ac |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | IFT88 |
| Gene ID: | 8100 |
| Uniprot ID: | IFT88_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_783195.2; NP_006522.2, NP_001340507.1; NP_001340498.1 |
| Specificity: | This antibody is expected to recognise many reported isoforms. |
| Immunogen Sequence: | KKRIDEDDFADEE |
| Function | Positively regulates primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. |
| Protein Name | Intraflagellar Transport Protein 88 HomologRecessive Polycystic Kidney Disease Protein Tg737 HomologTetratricopeptide Repeat Protein 10Tpr Repeat Protein 10 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620924Reactome: R-HSA-9613829Reactome: R-HSA-9615710Reactome: R-HSA-9646399 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCell ProjectionCiliumCilium Basal BodyFlagellumColocalizes With Entr1 And Gamma-Tubulin At The Basal Body Of Primary CiliaColocalizes With Entr1 And Pericentrin At The CentrosomeIn Sperm CellsLocalizes To The ManchetteHead-Tail Coupling Apparatus And Flagellum |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 88 Homolog antibodyAnti-Recessive Polycystic Kidney Disease Protein Tg737 Homolog antibodyAnti-Tetratricopeptide Repeat Protein 10 antibodyAnti-Tpr Repeat Protein 10 antibodyAnti-IFT88 antibodyAnti-TG737 antibodyAnti-TTC10 antibody |
Information sourced from Uniprot.org
