| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Interferon Lambda-3 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFNL3 |
| Gene ID: |
282617 |
| Uniprot ID: |
IFNL3_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFNL2/IFNL3 (NP_742151.2). |
| Immunogen Sequence: |
MTGDCMPVLVLMAAVLTVTG AVPVARLRGALPDARGCHIA QFKSLSPQELQAFKRAKDAL EESLLLKDCKCRSRLFPRTW DLRQLQVRERPVALEAELAL |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-3Ifn-Lambda-3Cytokine Zcyto22Interleukin-28bIl-28bInterleukin-28cIl-28c |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Lambda-3 antibodyAnti-Ifn-Lambda-3 antibodyAnti-Cytokine Zcyto22 antibodyAnti-Interleukin-28b antibodyAnti-Il-28b antibodyAnti-Interleukin-28c antibodyAnti-Il-28c antibodyAnti-IFNL3 antibodyAnti-IL28B antibodyAnti-IL28C antibodyAnti-ZCYTO22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
