Anti-Ifng antibody [X mg1.2] (STJA0001644)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Rat monoclonal anti-Interferon gamma for use in ICFC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICFC |
| Host | Rat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | X mg1.2 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Formulation | 0.2 ยตm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay. |
| Storage Instruction | This product can be stored at 2-8ยฐC for 12 months. Do not freeze. |
Target Information
| Gene Symbol | Ifng |
| Gene ID | 15978 |
| Uniprot ID | IFNG_MOUSE |
Additional Info
| Tissue Specificity | Released primarily from activated T lymphocytes. |
| Function | Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. |
| Protein Name | Interferon GammaIfn-Gamma |
| Database Links | Reactome: R-MMU-877300Reactome: -MMU-877312Reactome: -MMU-9732724 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Gamma antibodyAnti-Ifn-Gamma antibodyAnti-Ifng antibody |
Information sourced from Uniprot.org