Anti-IFI6 antibody (80-130) (STJ505935)

SKU:
STJ505935-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IFI6 (80-130) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: IFI6
Gene ID: 2537
Uniprot ID: IFI6_HUMAN
Immunogen Region: 80-130
Immunogen: Synthetic peptide take within amino acid region 80-130 on human Interferon alpha-inducible protein 6.
Function Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells. Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Modulates innate immune response mediated by RIGI by preventing its activation.
Protein Name Interferon Alpha-Inducible Protein 6
Interferon-Induced Protein 6-16
Ifi-6-16
Database Links Reactome: R-HSA-909733
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Mitochondrion Inner Membrane
Alternative Antibody Names Anti-Interferon Alpha-Inducible Protein 6 antibody
Anti-Interferon-Induced Protein 6-16 antibody
Anti-Ifi-6-16 antibody
Anti-IFI6 antibody
Anti-G1P3 antibody

Information sourced from Uniprot.org

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