| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IFI6 (1-130) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFI6 |
| Gene ID: |
2537 |
| Uniprot ID: |
IFI6_HUMAN |
| Immunogen Region: |
1-130 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human IFI6 (NP_002029.3). |
| Immunogen Sequence: |
MRQKAVSLFLCYLLLFTCSG VEAGKKKCSESSDSGSGFWK ALTFMAVGGGLAVAGLPALG FTGAGIAANSVAASLMSWSA ILNGGGVPAGGLVATLQSLG AGGSSVVIGNIGALMGYATH KYLDSEEDEE |
| Post Translational Modifications | Glycosylated. |
| Function | Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells. Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Modulates innate immune response mediated by RIGI by preventing its activation. |
| Protein Name | Interferon Alpha-Inducible Protein 6Interferon-Induced Protein 6-16Ifi-6-16 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Interferon Alpha-Inducible Protein 6 antibodyAnti-Interferon-Induced Protein 6-16 antibodyAnti-Ifi-6-16 antibodyAnti-IFI6 antibodyAnti-G1P3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
