| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IFI6 |
| Gene ID: | 2537 |
| Uniprot ID: | IFI6_HUMAN |
| Immunogen Region: | 1-130 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human IFI6 (NP_002029.3). |
| Immunogen Sequence: | MRQKAVSLFLCYLLLFTCSG VEAGKKKCSESSDSGSGFWK ALTFMAVGGGLAVAGLPALG FTGAGIAANSVAASLMSWSA ILNGGGVPAGGLVATLQSLG AGGSSVVIGNIGALMGYATH KYLDSEEDEE |
| Post Translational Modifications | Glycosylated. |
| Function | Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells. Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Modulates innate immune response mediated by RIGI by preventing its activation. |
| Protein Name | Interferon Alpha-Inducible Protein 6 Interferon-Induced Protein 6-16 Ifi-6-16 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Interferon Alpha-Inducible Protein 6 antibody Anti-Interferon-Induced Protein 6-16 antibody Anti-Ifi-6-16 antibody Anti-IFI6 antibody Anti-G1P3 antibody |
Information sourced from Uniprot.org