| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Interferon alpha-inducible protein 27, mitochondrial (1-80 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFI27 |
| Gene ID: |
3429 |
| Uniprot ID: |
IFI27_HUMAN |
| Immunogen Region: |
1-80 aa |
| Specificity: |
IFI27 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 1-80 |
| Function | Probable adapter protein involved in different biological processes. Part of the signaling pathways that lead to apoptosis. Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. Also functions in TNFSF10-induced apoptosis. May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. May thereby play a role in the vascular response to injury. In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV. May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A. Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21. |
| Protein Name | Interferon Alpha-Inducible Protein 27 - MitochondrialP27Interferon Alpha-Induced 11.5 Kda ProteinInterferon-Stimulated Gene 12a ProteinIsg12(AIsg12a |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | Mitochondrion MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneEndoplasmic Reticulum MembraneExclusive Localizations In Either The Nucleus Or The Mitochondrion Have Been Reported |
| Alternative Antibody Names | Anti-Interferon Alpha-Inducible Protein 27 - Mitochondrial antibodyAnti-P27 antibodyAnti-Interferon Alpha-Induced 11.5 Kda Protein antibodyAnti-Interferon-Stimulated Gene 12a Protein antibodyAnti-Isg12(A antibodyAnti-Isg12a antibodyAnti-IFI27 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
