| Post Translational Modifications | Ubiquitinated by TRIM21 via 'Lys-6'-linked ubiquitin chains leading to IFI27 mitochondrial migration. |
| Function | Probable adapter protein involved in different biological processes. Part of the signaling pathways that lead to apoptosis. Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. Also functions in TNFSF10-induced apoptosis. May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. May thereby play a role in the vascular response to injury. In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV. May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A. Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21. |
| Protein Name | Interferon Alpha-Inducible Protein 27 - MitochondrialP27Interferon Alpha-Induced 11.5 Kda ProteinInterferon-Stimulated Gene 12a ProteinIsg12(AIsg12a |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | Mitochondrion MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneEndoplasmic Reticulum MembraneExclusive Localizations In Either The Nucleus Or The Mitochondrion Have Been Reported |
| Alternative Antibody Names | Anti-Interferon Alpha-Inducible Protein 27 - Mitochondrial antibodyAnti-P27 antibodyAnti-Interferon Alpha-Induced 11.5 Kda Protein antibodyAnti-Interferon-Stimulated Gene 12a Protein antibodyAnti-Isg12(A antibodyAnti-Isg12a antibodyAnti-IFI27 antibody |
Information sourced from Uniprot.org
