| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Non-homologous end joining factor IFFO1 (387-437 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFFO1 |
| Gene ID: |
25900 |
| Uniprot ID: |
IFFO1_HUMAN |
| Immunogen Region: |
387-437 aa |
| Specificity: |
This antibody detects endogenous levels of IFFO1 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human IFFO1 at the amino acid range 387-437 |
| Function | Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation. Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites. |
| Protein Name | Non-Homologous End Joining Factor Iffo1Nhej Factor Iffo1Intermediate Filament Family Orphan 1Tumor Antigen Hom-Tes-103 |
| Cellular Localisation | NucleusNucleoplasmNucleus Inner MembraneNucleus MatrixMainly SolubleThe Remaining Is Localized In The Nuclear MatrixLocalized At Double-Strand Break (Dsb) Sites Near The Lamina And Nuclear Matrix Structures |
| Alternative Antibody Names | Anti-Non-Homologous End Joining Factor Iffo1 antibodyAnti-Nhej Factor Iffo1 antibodyAnti-Intermediate Filament Family Orphan 1 antibodyAnti-Tumor Antigen Hom-Tes-103 antibodyAnti-IFFO1 antibodyAnti-IFFO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
