| Function | Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation. Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites. |
| Protein Name | Non-Homologous End Joining Factor Iffo1Nhej Factor Iffo1Intermediate Filament Family Orphan 1Tumor Antigen Hom-Tes-103 |
| Cellular Localisation | NucleusNucleoplasmNucleus Inner MembraneNucleus MatrixMainly SolubleThe Remaining Is Localized In The Nuclear MatrixLocalized At Double-Strand Break (Dsb) Sites Near The Lamina And Nuclear Matrix Structures |
| Alternative Antibody Names | Anti-Non-Homologous End Joining Factor Iffo1 antibodyAnti-Nhej Factor Iffo1 antibodyAnti-Intermediate Filament Family Orphan 1 antibodyAnti-Tumor Antigen Hom-Tes-103 antibodyAnti-IFFO1 antibodyAnti-IFFO antibody |
Information sourced from Uniprot.org
