| Post Translational Modifications | Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli. Glycosylated. |
| Function | May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. |
| Protein Name | Radiation-Inducible Immediate-Early Gene Iex-1Differentiation-Dependent Gene 2 ProteinProtein Dif-2Immediate Early Protein Gly96Immediate Early Response 3 ProteinPacap-Responsive Gene 1 ProteinProtein Prg1 |
| Database Links | Reactome: R-HSA-6811558 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Radiation-Inducible Immediate-Early Gene Iex-1 antibodyAnti-Differentiation-Dependent Gene 2 Protein antibodyAnti-Protein Dif-2 antibodyAnti-Immediate Early Protein Gly96 antibodyAnti-Immediate Early Response 3 Protein antibodyAnti-Pacap-Responsive Gene 1 Protein antibodyAnti-Protein Prg1 antibodyAnti-IER3 antibodyAnti-DIF2 antibodyAnti-IEX1 antibodyAnti-PRG1 antibody |
Information sourced from Uniprot.org
