| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IDH3B |
| Gene ID: | 3420 |
| Uniprot ID: | IDH3B_HUMAN |
| Immunogen Region: | 35-170 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-170 of human IDH3B (NP_008830.2). |
| Immunogen Sequence: | ASRSQAEDVRVEGSFPVTML PGDGVGPELMHAVKEVFKAA AVPVEFQEHHLSEVQNMASE EKLEQVLSSMKENKVAIIGK IHTPMEYKGELASYDMRLRR KLDLFANVVHVKSLPGYMTR HNNLDLVIIREQTEGE |
| Function | Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. |
| Protein Name | Isocitrate Dehydrogenase Nad Subunit Beta - MitochondrialIsocitric Dehydrogenase Subunit BetaNad(+-Specific Icdh Subunit Beta |
| Database Links | Reactome: R-HSA-71403 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Isocitrate Dehydrogenase Nad Subunit Beta - Mitochondrial antibodyAnti-Isocitric Dehydrogenase Subunit Beta antibodyAnti-Nad(+-Specific Icdh Subunit Beta antibodyAnti-IDH3B antibody |
Information sourced from Uniprot.org