Anti-ICT1 antibody (30-206) (STJ113195)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ICT1 (30-206) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRPL58 |
| Gene ID | 3396 |
| Uniprot ID | ICT1_HUMAN |
| Immunogen Region | 30-206 |
| Immunogen Sequence | LHKQKDGTEFKSIYSLDKLY PESQGSDTAWRVPNGAKQAD SDIPLDRLTISYCRSSGPGG QNVNKVNSKAEVRFHLATAE WIAEPVRQKIAITHKNKINR LGELILTSESSRYQFRNLAD CLQKIRDMITEASQTPKEPT KEDVKLHRIRIENMNRERLR QKRIHSAVKTSRRVDMD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 30-206 of human ICT1 (NP_001536.1). |
Additional Info
| Tissue Specificity | Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells. |
| Post Translational Modifications | Methylation of glutamine in the GGQ triplet by HEMK1. |
| Function | Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. |
| Protein Name | Large Ribosomal Subunit Protein Ml6239s Ribosomal Protein L58 - MitochondrialMrp-L58Digestion Substraction 1Ds-1Immature Colon Carcinoma Transcript 1 ProteinPeptidyl-Trna Hydrolase Ict1 - Mitochondrial |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Large Ribosomal Subunit Protein Ml62 antibodyAnti-39s Ribosomal Protein L58 - Mitochondrial antibodyAnti-Mrp-L58 antibodyAnti-Digestion Substraction 1 antibodyAnti-Ds-1 antibodyAnti-Immature Colon Carcinoma Transcript 1 Protein antibodyAnti-Peptidyl-Trna Hydrolase Ict1 - Mitochondrial antibodyAnti-MRPL58 antibodyAnti-DS1 antibodyAnti-ICT1 antibody |
Information sourced from Uniprot.org