• Immunohistochemical analysis of paraffin-embedded human-tonsils, antibody was diluted at 1:100
  • Western blot analysis of 3T3 lysis using ICOS antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000

Anti-ICOS antibody (31-80 aa) (STJ97666)

SKU:
STJ97666

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Inducible T-cell costimulator (31-80 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ICOS
Gene ID: 29851
Uniprot ID: ICOS_HUMAN
Immunogen Region: 31-80 aa
Specificity: ICOS Polyclonal Antibody detects endogenous levels of ICOS protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human ICOS at the amino acid range 31-80
Post Translational Modifications N-glycosylated.
Function Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Protein Name Inducible T-Cell Costimulator
Activation-Inducible Lymphocyte Immunomediatory Molecule
Cd Antigen Cd278
Database Links Reactome: R-HSA-1257604 Q9Y6W8-1
Reactome: R-HSA-2219530 Q9Y6W8-1
Reactome: R-HSA-388841 Q9Y6W8-1
Reactome: R-HSA-6811558 Q9Y6W8-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Antibody Names Anti-Inducible T-Cell Costimulator antibody
Anti-Activation-Inducible Lymphocyte Immunomediatory Molecule antibody
Anti-Cd Antigen Cd278 antibody
Anti-ICOS antibody
Anti-AILIM antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance