| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ICMT |
| Gene ID: | 23463 |
| Uniprot ID: | ICMT_HUMAN |
| Immunogen Region: | 175-284 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 175-284 of human ICMT (NP_036537.1). |
| Immunogen Sequence: | KAAMFTAGSNFNHVVQNEKS DTHTLVTSGVYAWFRHPSYV GWFYWSIGTQVMLCNPICGV SYALTVWRFFRDRTEEEEIS LIHFFGEEYLEYKKRVPTGL PFIKGVKVDL |
| Tissue Specificity | Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons. |
| Function | Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. |
| Protein Name | Protein-S-Isoprenylcysteine O-MethyltransferaseIsoprenylcysteine CarboxylmethyltransferasePrenylated Protein Carboxyl MethyltransferasePpmtPrenylcysteine Carboxyl MethyltransferasePccmt |
| Database Links | Reactome: R-HSA-163841Reactome: R-HSA-9648002 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein-S-Isoprenylcysteine O-Methyltransferase antibodyAnti-Isoprenylcysteine Carboxylmethyltransferase antibodyAnti-Prenylated Protein Carboxyl Methyltransferase antibodyAnti-Ppmt antibodyAnti-Prenylcysteine Carboxyl Methyltransferase antibodyAnti-Pccmt antibodyAnti-ICMT antibodyAnti-PCCMT antibody |
Information sourced from Uniprot.org