Anti-Icam1 antibody (28-493 aa) (STJ11105185)

Name: Anti-Icam1 antibody (28-493 aa) (STJ11105185)
SKU: STJ11105185
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11105185

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Short Description	Rabbit polyclonal Icam1 (28-493 aa) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	Icam1
Gene ID	25464
Uniprot ID	ICAM1_RAT
Immunogen Region	28-493 aa
Immunogen Sequence	QVSIHPTEAFLPRGGSVQVN CSSSCEDENLGLGLETNWMK DELSSGHNWKLFKLSDIGED SRPLCFENCGTTQSSASATI TVYSFPERVELDPLPAWQQV GKNLILRCLVEGGAPRTQLS VVLLRGNETLSRQAVDGDPK EITFTVLASRGDHGANFSCF TELDLRPQGLSLFKNVSEVR QLRTFDLPTRVLKLDTPDLL EVGTQQKFLCSLEGLFPASE AQIYLEMGGQMLTLESTNS
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 28-493 of rat Icam1. (NP_037099.1).

Post Translational Modifications	Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Function	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
Protein Name	Intercellular Adhesion Molecule 1 Icam-1 Cd Antigen Cd54
Database Links	Reactome: R-RNO-198933 Reactome: -RNO-216083
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Intercellular Adhesion Molecule 1 antibody Anti-Icam-1 antibody Anti-Cd Antigen Cd54 antibody Anti-Icam1 antibody Anti-Icam-1 antibody

Information sourced from Uniprot.org