Anti-ICAM1 antibody (100-200 aa) [ABT-CD54] (STJ196917)

Name: Anti-ICAM1 antibody (100-200 aa) [ABT-CD54] (STJ196917)
SKU: STJ196917
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostMouse

ConjugationUnconjugated

IsotypeIgG1k

ImmunogenSynthesized peptide derived from the human CD54 at the amino acid range 100-200

STJ196917

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Short Description	Mouse monoclonal anti-Intercellular adhesion molecule 1 (100-200 aa) for use in IHC, IF and WB in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	IHC/IF/WB
Host	Mouse
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	ABT-CD54
Isotype	IgG1k
Conjugation	Unconjugated
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range	IHC-P 1:100-500 WB 1:200-1000 IF 1:100-500
Formulation	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	ICAM1
Gene ID	3383
Uniprot ID	ICAM1_HUMAN
Immunogen	Synthesized peptide derived from the human CD54 at the amino acid range 100-200
Immunogen Region	100-200 aa
Specificity	This antibody detects endogenous levels of human CD54. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section

Function	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Protein Name	Intercellular Adhesion Molecule 1 Icam-1 Major Group Rhinovirus Receptor Cd Antigen Cd54
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-216083 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-877300
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Intercellular Adhesion Molecule 1 antibody Anti-Icam-1 antibody Anti-Major Group Rhinovirus Receptor antibody Anti-Cd Antigen Cd54 antibody Anti-ICAM1 antibody

Information sourced from Uniprot.org