| Host: | Mouse |
| Applications: | IHC/IF/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Intercellular adhesion molecule 1 (100-200 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-CD54 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500 WB 1:200-1000 IF 1:100-500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ICAM1 |
| Gene ID: | 3383 |
| Uniprot ID: | ICAM1_HUMAN |
| Immunogen Region: | 100-200 aa |
| Specificity: | This antibody detects endogenous levels of human CD54. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section |
| Immunogen: | Synthesized peptide derived from the human CD54 at the amino acid range 100-200 |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. |
| Protein Name | Intercellular Adhesion Molecule 1 Icam-1 Major Group Rhinovirus Receptor Cd Antigen Cd54 |
| Database Links | Reactome: R-HSA-198933 Reactome: R-HSA-216083 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-877300 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Intercellular Adhesion Molecule 1 antibody Anti-Icam-1 antibody Anti-Major Group Rhinovirus Receptor antibody Anti-Cd Antigen Cd54 antibody Anti-ICAM1 antibody |
Information sourced from Uniprot.org