| Post Translational Modifications | Phosphorylated at Ser-32 and Ser-36 by IKKA/CHUK and IKKB/IKBKB.disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is prerequisite to recognition by the SCF(FBXW11) and SCF(BTRC) complexes, leading to polyubiquitination and subsequent degradation. Polyubiquitinated at Lys-21 and/or Lys-22 following phosphorylation at Ser-32 and Ser-36. Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3. Ubiquitin chain elongation is then performed by CDC34 in cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. The resulting polyubiquitination leads to protein degradation. Also ubiquitinated by the SCF(BTRC) complex following stimulus-dependent phosphorylation at Ser-32 and Ser-36. Deubiquitinated by USP38, leading to NF-kappa-B inhibition. Sumoylated.sumoylation requires the presence of the nuclear import signal. Sumoylation blocks ubiquitination and proteasome-mediated degradation of the protein thereby increasing the protein stability. Hydroxylated by HIF1AN. |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Protein Name | Nf-Kappa-B Inhibitor AlphaI-Kappa-B-AlphaIkb-AlphaIkappabalphaRl/If-1 |
| Database Links | Reactome: R-RNO-1169091Reactome: -RNO-1810476Reactome: -RNO-209560Reactome: -RNO-445989Reactome: -RNO-4755510Reactome: -RNO-5689880Reactome: -RNO-9020702Reactome: -RNO-933542 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And The Cytoplasm By A Nuclear Localization Signal (Nls) And A Crm1-Dependent Nuclear Export |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Alpha antibodyAnti-I-Kappa-B-Alpha antibodyAnti-Ikb-Alpha antibodyAnti-Ikappabalpha antibodyAnti-Rl/If-1 antibodyAnti-Nfkbia antibodyAnti-Ikba antibody |
Information sourced from Uniprot.org
