| Host: | Rabbit |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HYOU1 |
| Gene ID: | 10525 |
| Uniprot ID: | HYOU1_HUMAN |
| Immunogen Region: | 1-140 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ORP150/GRP170/HSP12A (NP_001124463.1). |
| Immunogen Sequence: | MADKVRRQRPRRRVCWALVA VLLADLLALSDTLAVMSVDL GSESMKVAIVKPGVPMEIVL NKESRRKTPVIVTLKENERF FGDSAASMAIKNPKATLRYF QHLLGKQADNPHVALYQARF PEHELTFDPQRQTVHFQISS |
| Tissue Specificity | Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. |
| Function | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. |
| Protein Name | Hypoxia Up-Regulated Protein 1 150 Kda Oxygen-Regulated Protein Orp-150 170 Kda Glucose-Regulated Protein Grp-170 Heat Shock Protein Family H Member 4 |
| Database Links | Reactome: R-HSA-3000484 Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Hypoxia Up-Regulated Protein 1 antibody Anti-150 Kda Oxygen-Regulated Protein antibody Anti-Orp-150 antibody Anti-170 Kda Glucose-Regulated Protein antibody Anti-Grp-170 antibody Anti-Heat Shock Protein Family H Member 4 antibody Anti-HYOU1 antibody Anti-GRP170 antibody Anti-HSPH4 antibody Anti-ORP150 antibody |
Information sourced from Uniprot.org