Anti-HVCN1 antibody (STJA0008167)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HVCN1
General Information
| Short Description | Rabbit polyclonal anti-Voltage-gated hydrogen channel 1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HVCN1 |
| Gene ID | 84329 |
| Uniprot ID | HVCN1_HUMAN |
| Immunogen | Synthesized peptide derived from human HVCN1 |
| Specificity | This antibody detects endogenous levels of HVCN1 at Human, Mouse |
Additional Info
| Post Translational Modifications | Proteolytically cleaved in sperm. The cleaved protomer forms homodimers and heterodimers with the full-length protomer. It confers reduced dependence to intracellular pH changes. Phosphorylated in vitro by PRKCD. Phosphorylation may enhance channel gating. |
| Function | Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain. Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation. Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst. Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa. |
| Protein Name | Voltage-Gated Hydrogen Channel 1Hydrogen Voltage-Gated Channel 1Hv1Voltage Sensor Domain-Only Protein |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-1300642Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCytoplasmic VesiclePhagosome MembraneCell ProjectionCiliumFlagellum MembraneDetected Within The Principal Piece Of The Sperm FlagellumDetected Mainly At Intracellular Membranes Upon Overexpression In Hela Cells |
| Alternative Antibody Names | Anti-Voltage-Gated Hydrogen Channel 1 antibodyAnti-Hydrogen Voltage-Gated Channel 1 antibodyAnti-Hv1 antibodyAnti-Voltage Sensor Domain-Only Protein antibodyAnti-HVCN1 antibodyAnti-VSOP antibodyAnti-UNQ578 antibodyAnti-PRO1140 antibody |
Information sourced from Uniprot.org