![Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/201176/413274/STJN000563-SDS-PAGE-1__38461.1749232756.jpg?c=1 "Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)")
![Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/201176/413274/STJN000563-SDS-PAGE-1__38461.1749232756.jpg?c=1 "Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)")
Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Folate Receptor Alpha is suitable for use in ELISA and Flow Cytometry research applications. |
| Applications | ELISA/FC |
| Host | Alpaca |
| Reactivity | Human/Cynomolgus |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2048 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1.41 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | FOLR1 |
| Gene ID | 2348 |
| Uniprot ID | FOLR1_HUMAN |
Additional Info
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Protein Name | Folate Receptor AlphaFr-AlphaAdult Folate-Binding ProteinFbpFolate Receptor 1Folate Receptor - AdultKb Cells FbpOvarian Tumor-Associated Antigen Mov18 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Nanobody Names | Anti-Folate Receptor Alpha nanobodyAnti-Fr-Alpha nanobodyAnti-Adult Folate-Binding Protein nanobodyAnti-Fbp nanobodyAnti-Folate Receptor 1 nanobodyAnti-Folate Receptor - Adult nanobodyAnti-Kb Cells Fbp nanobodyAnti-Ovarian Tumor-Associated Antigen Mov18 nanobodyAnti-FOLR1 nanobodyAnti-FOLR nanobody |
Information sourced from Uniprot.org