| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Protein Name | Folate Receptor AlphaFr-AlphaAdult Folate-Binding ProteinFbpFolate Receptor 1Folate Receptor - AdultKb Cells FbpOvarian Tumor-Associated Antigen Mov18 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Nanobody Names | Anti-Folate Receptor Alpha nanobodyAnti-Fr-Alpha nanobodyAnti-Adult Folate-Binding Protein nanobodyAnti-Fbp nanobodyAnti-Folate Receptor 1 nanobodyAnti-Folate Receptor - Adult nanobodyAnti-Kb Cells Fbp nanobodyAnti-Ovarian Tumor-Associated Antigen Mov18 nanobodyAnti-FOLR1 nanobodyAnti-FOLR nanobody |
Information sourced from Uniprot.org
![Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/201176/413274/STJN000563-SDS-PAGE-1__38461.1749232756.jpg?c=1 "Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)")
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