| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-5-hydroxytryptamine receptor 6 (221-270 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HTR6 |
| Gene ID: | 3362 |
| Uniprot ID: | 5HT6R_HUMAN |
| Immunogen Region: | 221-270 aa |
| Specificity: | SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human 5-HT-6 at the amino acid range 221-270 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of mTOR signaling. |
| Protein Name | 5-Hydroxytryptamine Receptor 65-Ht-65-Ht6Serotonin Receptor 6 |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 6 antibodyAnti-5-Ht-6 antibodyAnti-5-Ht6 antibodyAnti-Serotonin Receptor 6 antibodyAnti-HTR6 antibody |
Information sourced from Uniprot.org