| Tissue Specificity | Isoform 5-HT4(A): Expressed in ileum, brain, and atrium, but not in the ventricle. Isoform 5-HT4(E): Mainly expressed in atria and cardiac ventricle. Isoform 5-HT4(I): Expressed in all cardiovascular tissues analyzed. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. |
| Protein Name | 5-Hydroxytryptamine Receptor 45-Ht-45-Ht4Serotonin Receptor 4 |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome MembraneInteraction With Snx27 Mediates Recruitment To Early EndosomesWhile Interaction With Nherf1 And Ezr Might Target The Protein To Specialized Subcellular RegionsSuch As Microvilli |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 4 antibodyAnti-5-Ht-4 antibodyAnti-5-Ht4 antibodyAnti-Serotonin Receptor 4 antibodyAnti-HTR4 antibody |
Information sourced from Uniprot.org
