| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HTR4 |
| Gene ID: |
3360 |
| Uniprot ID: |
5HT4R_HUMAN |
| Immunogen Region: |
350-384 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 350-384 of human HTR4 (NP_000861.1). |
| Immunogen Sequence: |
TINGSTHVLRDAVECGGQWE SQCHPPATSPLVAAQ |
| Tissue Specificity | Isoform 5-HT4(A): Expressed in ileum, brain, and atrium, but not in the ventricle. Isoform 5-HT4(E): Mainly expressed in atria and cardiac ventricle. Isoform 5-HT4(I): Expressed in all cardiovascular tissues analyzed. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. |
| Protein Name | 5-Hydroxytryptamine Receptor 45-Ht-45-Ht4Serotonin Receptor 4 |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome MembraneInteraction With Snx27 Mediates Recruitment To Early EndosomesWhile Interaction With Nherf1 And Ezr Might Target The Protein To Specialized Subcellular RegionsSuch As Microvilli |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 4 antibodyAnti-5-Ht-4 antibodyAnti-5-Ht4 antibodyAnti-Serotonin Receptor 4 antibodyAnti-HTR4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
