| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Htr3b-Rat (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 50kDa band observed in Rat Brain lysates (calculated MW of 50.3kDa according to NP_071525.1). Recommended concentration: 0.03-0.1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: | Internal |
| Accession Number: | NP_071525.1 |
| Immunogen Sequence: | QEDIENDKRSFLND |
| Post Translational Modifications | N-glycosylation is required for membrane localization. |
| Function | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. |
| Protein Name | 5-Hydroxytryptamine Receptor 3b5-Ht3-B5-Ht3bSerotonin Receptor 3b |
| Database Links | Reactome: R-RNO-112314 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPresumably Retained Within The Endoplasmic Reticulum Unless Complexed With Htr3a |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 3b antibodyAnti-5-Ht3-B antibodyAnti-5-Ht3b antibodyAnti-Serotonin Receptor 3b antibodyAnti-Htr3b antibody |
Information sourced from Uniprot.org
