| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HTR3A |
| Gene ID: | 3359 |
| Uniprot ID: | 5HT3A_HUMAN |
| Immunogen Region: | 24-484 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-241 of human HTR3A (NP_000860.2). |
| Immunogen Sequence: | LAQGEARRSRNTTRPALLRL SDYLLTNYRKGVRPVRDWRK PTTVSIDVIVYAILNVDEKN QVLTTYIWYRQYWTDEFLQW NPEDFDNITKLSIPTDSIWV PDILINEFVDVGKSPNIPYV YIRHQGEVQNYKPLQVVTAC SLDIYNFPFDVQNCSLTFTS WLHTIQDINISLWRLPEKVK SDRSVFMNQGEWELLGVLPY FREFSMESSNYYAEMKFY |
| Tissue Specificity | Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. |
| Function | Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. |
| Protein Name | 5-Hydroxytryptamine Receptor 3a5-Ht3-A5-Ht3a5-Hydroxytryptamine Receptor 35-Ht-35-Ht3rSerotonin Receptor 3aSerotonin-Gated Ion Channel Receptor |
| Database Links | Reactome: R-HSA-112314 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 3a antibodyAnti-5-Ht3-A antibodyAnti-5-Ht3a antibodyAnti-5-Hydroxytryptamine Receptor 3 antibodyAnti-5-Ht-3 antibodyAnti-5-Ht3r antibodyAnti-Serotonin Receptor 3a antibodyAnti-Serotonin-Gated Ion Channel Receptor antibodyAnti-HTR3A antibodyAnti-5HT3R antibodyAnti-HTR3 antibody |
Information sourced from Uniprot.org