Anti-HTR2A nanobody [SAA1362] (STJN000184)

Anti-HTR2A nanobody [SAA1362] (STJN000184)

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STJN000184
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-5-Hydroxytryptamine Receptor 2a is suitable for use in Immunoprecipitation research applications.
Clonality : Monoclonal
Clone ID : SAA1362
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: HTR2A
Gene ID: 3356
Uniprot ID: 5HT2A_HUMAN
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.
Protein Name 5-Hydroxytryptamine Receptor 2a
5-Ht-2
5-Ht-2a
Serotonin Receptor 2a
Database Links Reactome: R-HSA-390666
Reactome: R-HSA-416476
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendrite
Axon
Cytoplasmic Vesicle
Membrane
Caveola
Presynapse
Alternative Nanobody Names Anti-5-Hydroxytryptamine Receptor 2a nanobody
Anti-5-Ht-2 nanobody
Anti-5-Ht-2a nanobody
Anti-Serotonin Receptor 2a nanobody
Anti-HTR2A nanobody
Anti-HTR2 nanobody

Information sourced from Uniprot.org

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