| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HTR1D |
| Gene ID: | 3352 |
| Uniprot ID: | 5HT1D_HUMAN |
| Immunogen Region: | 150-250 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human HTR1D (NP_000855.1). |
| Immunogen Sequence: | RTAGHAATMIAIVWAISICI SIPPLFWRQAKAQEEMSDCL VNTSQISYTIYSTCGAFYIP SVLLIILYGRIYRAARNRIL NPPSLYGKRFTTAHLITGSA G |
| Tissue Specificity | Detected in brain neocortex and caudate nucleus (at protein level). |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. |
| Protein Name | 5-Hydroxytryptamine Receptor 1d 5-Ht-1d 5-Ht1d Serotonin 1d Alpha Receptor 5-Ht-1d-Alpha Serotonin Receptor 1d |
| Database Links | Reactome: R-HSA-390666 Reactome: R-HSA-418594 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1d antibody Anti-5-Ht-1d antibody Anti-5-Ht1d antibody Anti-Serotonin 1d Alpha Receptor antibody Anti-5-Ht-1d-Alpha antibody Anti-Serotonin Receptor 1d antibody Anti-HTR1D antibody Anti-HTR1DA antibody Anti-HTRL antibody |
Information sourced from Uniprot.org