| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-5-hydroxytryptamine receptor 1A (291-340 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HTR1A |
| Gene ID: | 3350 |
| Uniprot ID: | 5HT1A_HUMAN |
| Immunogen Region: | 291-340 aa |
| Specificity: | SR-1A Polyclonal Antibody detects endogenous levels of SR-1A protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human 5-HT-1A at the amino acid range 291-340 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. |
| Protein Name | 5-Hydroxytryptamine Receptor 1a 5-Ht-1a 5-Ht1a G-21 Serotonin Receptor 1a |
| Database Links | Reactome: R-HSA-390666 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendrite |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1a antibody Anti-5-Ht-1a antibody Anti-5-Ht1a antibody Anti-G-21 antibody Anti-Serotonin Receptor 1a antibody Anti-HTR1A antibody Anti-ADRB2RL1 antibody Anti-ADRBRL1 antibody |
Information sourced from Uniprot.org