| Tissue Specificity | Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. |
| Function | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. |
| Protein Name | Heat Shock Protein 75 Kda - MitochondrialHsp 75Heat Shock Protein Family C Member 5Tnfr-Associated Protein 1Tumor Necrosis Factor Type 1 Receptor-Associated ProteinTrap-1 |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-71403 |
| Cellular Localisation | MitochondrionMitochondrion Inner MembraneMitochondrion Matrix |
| Alternative Antibody Names | Anti-Heat Shock Protein 75 Kda - Mitochondrial antibodyAnti-Hsp 75 antibodyAnti-Heat Shock Protein Family C Member 5 antibodyAnti-Tnfr-Associated Protein 1 antibodyAnti-Tumor Necrosis Factor Type 1 Receptor-Associated Protein antibodyAnti-Trap-1 antibodyAnti-TRAP1 antibodyAnti-HSP75 antibodyAnti-HSPC5 antibody |
Information sourced from Uniprot.org
