| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Hsf2bp |
| Gene ID: |
74377 |
| Uniprot ID: |
HSF2B_MOUSE |
| Immunogen Region: |
1-338 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-338 of mouse HSF2BP (NP_083178.1). |
| Immunogen Sequence: |
MAATVGDGSGTEEACRNMES KEEFVKVRKKDLERLTTEVM QIRDFLPRILNGELLESFQK LKMVEKNLERKEQELEQLIM DREHFKARLETAQADSGREK KEKLALRQQLNEAKQQLLQQ AEYCTQMGAVTCTLLWGVSS SEEVVKTILGGDKALKFFNI TGQTMESFVKSLDGDVKEVD SDENQFVFALAGIVTNVAAI ACGREFLVNSSRVLLDTMLQ LLGDLKPGQCTKLKVLMLM |
| Tissue Specificity | Expressed in testis and, to a lesser extent, in lung and muscle. |
| Post Translational Modifications | Sumoylated by UBE2I in response to MEKK1-mediated stimuli. |
| Function | Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Required for proper recombinase recruitment in female meiosis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis. |
| Protein Name | Heat Shock Factor 2-Binding Protein |
| Cellular Localisation | CytoplasmChromosomeLocalizes On Double-Strand Breaks (Dsbs) In Mitotic And Meiotic Chromosomes |
| Alternative Antibody Names | Anti-Heat Shock Factor 2-Binding Protein antibodyAnti-Hsf2bp antibodyAnti-Meilb2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
