| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
HSD3B7 |
| Gene ID: |
80270 |
| Uniprot ID: |
3BHS7_HUMAN |
| Immunogen Region: |
120-280 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human HSD3B7 (NP_079469.2). |
| Immunogen Sequence: |
GTRFLVYTSSMEVVGPNTKG HPFYRGNEDTPYEAVHRHPY PCSKALAEWLVLEANGRKVR GGLPLVTCALRPTGIYGEGH QIMRDFYRQGLRLGGWLFRA IPASVEHGRVYVGNVAWMHV LAARELEQRATLMGGQVYFC YDGSPYRSYEDFNMEFLGPC G |
| Function | The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. |
| Protein Name | 3 Beta-Hydroxysteroid Dehydrogenase Type 73 Beta-Hydroxysteroid Dehydrogenase Type Vii3-Beta-Hsd Vii3-Beta-Hydroxy-Delta(5-C27 Steroid OxidoreductaseC(27 3-Beta-HsdCholest-5-Ene-3-Beta -7-Alpha-Diol 3-Beta-Dehydrogenase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-3 Beta-Hydroxysteroid Dehydrogenase Type 7 antibodyAnti-3 Beta-Hydroxysteroid Dehydrogenase Type Vii antibodyAnti-3-Beta-Hsd Vii antibodyAnti-3-Beta-Hydroxy-Delta(5-C27 Steroid Oxidoreductase antibodyAnti-C(27 3-Beta-Hsd antibodyAnti-Cholest-5-Ene-3-Beta -7-Alpha-Diol 3-Beta-Dehydrogenase antibodyAnti-HSD3B7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
