| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HSD17B8 (1-261) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSD17B8 |
| Gene ID: |
7923 |
| Uniprot ID: |
DHB8_HUMAN |
| Immunogen Region: |
1-261 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human HSD17B8 (NP_055049.1). |
| Immunogen Sequence: |
MASQLQNRLRSALALVTGAG SGIGRAVSVRLAGEGATVAA CDLDRAAAQETVRLLGGPGS KEGPPRGNHAAFQADVSEAR AARCLLEQVQACFSRPPSVV VSCAGITQDEFLLHMSEDDW DKVIAVNLKGTFLVTQAAAQ ALVSNGCRGSIINISSIVGK VGNVGQTNYAASKAGVIGLT QTAARELGRHGIRCNSVLPG FIATPMTQKVPQKVVDKITE MIPMGHLGDPEDVADVVAF |
| Tissue Specificity | Widely expressed, particularly abundant in prostate, placenta and kidney. Expressed at protein level in various tissues like brain, cerebellum, heart, lung, kidney, ovary, testis, adrenals and prostate. |
| Function | Required for the solubility and assembly of the heterotetramer 3-ketoacyl-acyl carrier protein (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference.this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (Probable). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol. |
| Protein Name | (3r-3-Hydroxyacyl-Coa Dehydrogenase17-Beta-Hydroxysteroid Dehydrogenase 817-Beta-Hsd 8Hsd17b83-Ketoacyl-Acyl-Carrier-Protein Reductase Alpha SubunitKar Alpha Subunit3-Oxoacyl-Acyl-Carrier-Protein ReductaseEstradiol 17-Beta-Dehydrogenase 8Protein Ke6Ke6Short Chain Dehydrogenase/Reductase Family 30c Member 1Testosterone 17-Beta-Dehydrogenase 8 |
| Database Links | Reactome: R-HSA-75105 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-(3r-3-Hydroxyacyl-Coa Dehydrogenase antibodyAnti-17-Beta-Hydroxysteroid Dehydrogenase 8 antibodyAnti-17-Beta-Hsd 8 antibodyAnti-Hsd17b8 antibodyAnti-3-Ketoacyl-Acyl-Carrier-Protein Reductase Alpha Subunit antibodyAnti-Kar Alpha Subunit antibodyAnti-3-Oxoacyl-Acyl-Carrier-Protein Reductase antibodyAnti-Estradiol 17-Beta-Dehydrogenase 8 antibodyAnti-Protein Ke6 antibodyAnti-Ke6 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 30c Member 1 antibodyAnti-Testosterone 17-Beta-Dehydrogenase 8 antibodyAnti-HSD17B8 antibodyAnti-FABGL antibodyAnti-HKE6 antibodyAnti-RING2 antibodyAnti-SDR30C1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
