| Function | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. |
| Protein Name | Peroxisomal Multifunctional Enzyme Type 2Mfe-217-Beta-Hydroxysteroid Dehydrogenase 417-Beta-Hsd 4D-Bifunctional ProteinDbpMultifunctional Protein 2Mfp-2Short Chain Dehydrogenase/Reductase Family 8c Member 1 Cleaved Into -3r-Hydroxyacyl-Coa Dehydrogenase - Enoyl-Coa Hydratase 23-Alpha -7-Alpha -12-Alpha-Trihydroxy-5-Beta-Cholest-24-Enoyl-Coa Hydratase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-2046106Reactome: R-HSA-389887Reactome: R-HSA-390247Reactome: R-HSA-9033241Reactome: R-HSA-9033500 |
| Cellular Localisation | Peroxisome |
| Alternative Antibody Names | Anti-Peroxisomal Multifunctional Enzyme Type 2 antibodyAnti-Mfe-2 antibodyAnti-17-Beta-Hydroxysteroid Dehydrogenase 4 antibodyAnti-17-Beta-Hsd 4 antibodyAnti-D-Bifunctional Protein antibodyAnti-Dbp antibodyAnti-Multifunctional Protein 2 antibodyAnti-Mfp-2 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 8c Member 1 Cleaved Into - antibodyAnti-3r-Hydroxyacyl-Coa Dehydrogenase - Enoyl-Coa Hydratase 2 antibodyAnti-3-Alpha -7-Alpha -12-Alpha-Trihydroxy-5-Beta-Cholest-24-Enoyl-Coa Hydratase antibodyAnti-HSD17B4 antibodyAnti-EDH17B4 antibodyAnti-SDR8C1 antibody |
Information sourced from Uniprot.org
