Anti-HSD17B2 antibody (100-387) (STJ24083)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HSD17B2 (100-387) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSD17B2 |
| Gene ID | 3294 |
| Uniprot ID | DHB2_HUMAN |
| Immunogen Region | 100-387 |
| Immunogen Sequence | KYLDELGFTVFAGVLNENGP GAEELRRTCSPRLSVLQMDI TKPVQIKDAYSKVAAMLQDR GLWAVINNAGVLGFPTDGEL LLMTDYKQCMAVNFFGTVEV T |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human HSD17B2 (NP_002144.1). |
Additional Info
| Tissue Specificity | Expressed in placenta. |
| Function | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. |
| Protein Name | 17-Beta-Hydroxysteroid Dehydrogenase Type 217-Beta-Hsd 220 Alpha-Hydroxysteroid Dehydrogenase20-Alpha-HsdE2dhEstradiol 17-Beta-Dehydrogenase 2Microsomal 17-Beta-Hydroxysteroid DehydrogenaseShort Chain Dehydrogenase/Reductase Family 9c Member 2Testosterone 17-Beta-Dehydrogenase |
| Database Links | Reactome: R-HSA-193144 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-17-Beta-Hydroxysteroid Dehydrogenase Type 2 antibodyAnti-17-Beta-Hsd 2 antibodyAnti-20 Alpha-Hydroxysteroid Dehydrogenase antibodyAnti-20-Alpha-Hsd antibodyAnti-E2dh antibodyAnti-Estradiol 17-Beta-Dehydrogenase 2 antibodyAnti-Microsomal 17-Beta-Hydroxysteroid Dehydrogenase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 9c Member 2 antibodyAnti-Testosterone 17-Beta-Dehydrogenase antibodyAnti-HSD17B2 antibodyAnti-EDH17B2 antibodyAnti-SDR9C2 antibody |
Information sourced from Uniprot.org