| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HS2ST1 |
| Gene ID: | 9653 |
| Uniprot ID: | HS2ST_HUMAN |
| Immunogen Region: | 1-229 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human HS2ST1 (NP_001127964.1). |
| Immunogen Sequence: | MGLLRIMMPPKLQLLAVVAF AVAMLFLENQIQKLEESRSK LERAIARHEVREIEQRHTMD GPRQDATLDEEEDMVIIYNR VPKTASTSFTNIAYDLCAKN KYHVLHINTTKNNPVMSLQD QVRFVKNITSWKEMKPGFYH GHVSYLDFAKFGVKKKPIYI NVIRDPIERLVSYYYFLRFG DDYRPGLRRRKQGDKKTFDE CVAEGGSDCAPEKLWLQIPF FCGHSSECW |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues. |
| Protein Name | Heparan Sulfate 2-O-Sulfotransferase 12-O-Sulfotransferase2ost |
| Database Links | Reactome: R-HSA-2022928 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Heparan Sulfate 2-O-Sulfotransferase 1 antibodyAnti-2-O-Sulfotransferase antibodyAnti-2ost antibodyAnti-HS2ST1 antibodyAnti-HS2ST antibodyAnti-KIAA0448 antibody |
Information sourced from Uniprot.org