Anti-HRSP12 antibody (1-137) (STJ24082)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HRSP12 (1-137) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RIDA |
| Gene ID | 10247 |
| Uniprot ID | RIDA_HUMAN |
| Immunogen Region | 1-137 |
| Immunogen Sequence | MSSLIRRVISTAKAPGAIGP YSQAVLVDRTIYISGQIGMD PSSGQLVSGGVAEEAKQALK NMGEILKAAGCDFTNVVKTT VLLADINDFNTVNEIYKQYF KSNFPARAAYQVAALPKGSR IEIEAVAIQGPLTTASL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human HRSP12 (NP_005827.1). |
Additional Info
| Tissue Specificity | Expressed predominantly in liver and kidney. Lower levels in lung and brain. |
| Function | Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage. |
| Protein Name | 2-Iminobutanoate/2-Iminopropanoate Deaminase14.5 Kda Translational Inhibitor ProteinHp14.5P14.5Heat-Responsive Protein 12Reactive Intermediate Imine Deaminase A HomologTranslation Inhibitor L-Psp RibonucleaseUk114 Antigen Homolog |
| Database Links | Reactome: R-HSA-8849175 |
| Cellular Localisation | CytoplasmNucleusPeroxisomeMitochondrionMostly Cytoplasmic ButIn Less Differentiated Cells Occasionally Nuclear |
| Alternative Antibody Names | Anti-2-Iminobutanoate/2-Iminopropanoate Deaminase antibodyAnti-14.5 Kda Translational Inhibitor Protein antibodyAnti-Hp14.5 antibodyAnti-P14.5 antibodyAnti-Heat-Responsive Protein 12 antibodyAnti-Reactive Intermediate Imine Deaminase A Homolog antibodyAnti-Translation Inhibitor L-Psp Ribonuclease antibodyAnti-Uk114 Antigen Homolog antibodyAnti-RIDA antibodyAnti-HRSP12 antibody |
Information sourced from Uniprot.org