| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HRSP12 (1-137) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RIDA |
| Gene ID: |
10247 |
| Uniprot ID: |
RIDA_HUMAN |
| Immunogen Region: |
1-137 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human HRSP12 (NP_005827.1). |
| Immunogen Sequence: |
MSSLIRRVISTAKAPGAIGP YSQAVLVDRTIYISGQIGMD PSSGQLVSGGVAEEAKQALK NMGEILKAAGCDFTNVVKTT VLLADINDFNTVNEIYKQYF KSNFPARAAYQVAALPKGSR IEIEAVAIQGPLTTASL |
| Tissue Specificity | Expressed predominantly in liver and kidney. Lower levels in lung and brain. |
| Function | Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage. |
| Protein Name | 2-Iminobutanoate/2-Iminopropanoate Deaminase14.5 Kda Translational Inhibitor ProteinHp14.5P14.5Heat-Responsive Protein 12Reactive Intermediate Imine Deaminase A HomologTranslation Inhibitor L-Psp RibonucleaseUk114 Antigen Homolog |
| Database Links | Reactome: R-HSA-8849175 |
| Cellular Localisation | CytoplasmNucleusPeroxisomeMitochondrionMostly Cytoplasmic ButIn Less Differentiated Cells Occasionally Nuclear |
| Alternative Antibody Names | Anti-2-Iminobutanoate/2-Iminopropanoate Deaminase antibodyAnti-14.5 Kda Translational Inhibitor Protein antibodyAnti-Hp14.5 antibodyAnti-P14.5 antibodyAnti-Heat-Responsive Protein 12 antibodyAnti-Reactive Intermediate Imine Deaminase A Homolog antibodyAnti-Translation Inhibitor L-Psp Ribonuclease antibodyAnti-Uk114 Antigen Homolog antibodyAnti-RIDA antibodyAnti-HRSP12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
