| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HPSE2 |
| Gene ID: | 60495 |
| Uniprot ID: | HPSE2_HUMAN |
| Immunogen Region: | 42-242 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-242 of human HPSE2 (NP_068600.4). |
| Immunogen Sequence: | GDRRPLPVDRAAGLKEKTLI LLDVSTKNPVRTVNENFLSL QLDPSIIHDGWLDFLSSKRL VTLARGLSPAFLRFGGKRTD FLQFQNLRNPAKSRGGPGPD YYLKNYEDDIVRSDVALDKQ KGCKIAQHPDVMLELQREKA AQMHLVLLKEQFSNTYSNLI LTARSLDKLYNFADCSGLHL IFALNALRRNPNNSWNSSSA L |
| Tissue Specificity | Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues. |
| Function | Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). |
| Protein Name | Inactive Heparanase-2Hpa2 |
| Database Links | Reactome: R-HSA-2024096 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Inactive Heparanase-2 antibodyAnti-Hpa2 antibodyAnti-HPSE2 antibodyAnti-HPA2 antibody |
Information sourced from Uniprot.org