Host: | Rabbit |
Applications: | WB/IF/ICC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | HPS4 |
Gene ID: | 89781 |
Uniprot ID: | HPS4_HUMAN |
Immunogen Region: | 387-708 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 387-708 of human HPS4 (NP_071364.4). |
Immunogen Sequence: | FAFLHVPVPDGRAPYCKASL SASSSLEPTPPEDTAISSLR PPSAPEMLTQHGAQEQLEDH PGHSSQAPIPRADPLPRRTR RPLLLPRLDPGQRGNKLPTG EQGLDEDVDGVCESHAAPGL ECSSGSANCQGAGPSADGIS SRLTPAESCMGLVRMNLYTH CVKGLVLSLLAEEPLLGDSA AIEEVYHSSLASLNGLEVHL KETLPRDEAASTSSTYNFTH YDRIQSLLMANLPQVATPQ |
Function | Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. |
Protein Name | Bloc-3 Complex Member Hps4Hermansky-Pudlak Syndrome 4 ProteinLight-Ear Protein Homolog |
Database Links | Reactome: R-HSA-8876198 |
Alternative Antibody Names | Anti-Bloc-3 Complex Member Hps4 antibodyAnti-Hermansky-Pudlak Syndrome 4 Protein antibodyAnti-Light-Ear Protein Homolog antibodyAnti-HPS4 antibodyAnti-KIAA1667 antibody |
Information sourced from Uniprot.org