| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HPR |
| Gene ID: | 3250 |
| Uniprot ID: | HPTR_HUMAN |
| Immunogen Region: | 20-348 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-348 of human HPR (NP_066275.3). |
| Immunogen Sequence: | LYSGNDVTDISDDRFPKPPE IANGYVEHLFRYQCKNYYRL RTEGDGVYTLNDKKQWINKA VGDKLPECEAVCGKPKNPAN PVQRILGGHLDAKGSFPWQA KMVSHHNLTTGATLINEQWL LTTAKNLFLNHSENATAKDI APTLTLYVGKKQLVEIEKVV LHPNYHQVDIGLIKLKQKVL VNERVMPICLPSKNYAEVGR VGYVSGWGQSDNFKLTDHLK YVMLPVADQYDCITHYEGS |
| Tissue Specificity | In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines. |
| Function | Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron. |
| Protein Name | Haptoglobin-Related Protein |
| Database Links | Reactome: R-HSA-2168880 |
| Cellular Localisation | SecretedSecreted Into Blood Plasma And Associated With Subtypes Of High Density Lipoproteins (Hdl) |
| Alternative Antibody Names | Anti-Haptoglobin-Related Protein antibodyAnti-HPR antibody |
Information sourced from Uniprot.org