| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HP1BP3 |
| Gene ID: | 50809 |
| Uniprot ID: | HP1B3_HUMAN |
| Immunogen Region: | 1-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human HP1BP3 (NP_057371.2). |
| Immunogen Sequence: | MATDTSQGELVHPKALPLIV GAQLIHADKLGEKVEDSTMP IRRTVNSTRETPPKSKLAEG EEEKPEPDISSEESVSTVEE QENETPPATSSEAEQPKGEP ENEEKEENKSSEETKKDEKD QSKEKEKKVKKTIPSWATLS ASQLARAQKQTPMASSPRPK |
| Function | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal. |
| Protein Name | Heterochromatin Protein 1-Binding Protein 3Protein Hp1-Bp74 |
| Cellular Localisation | NucleusChromosomeLocalized In Nuclei But Not In Nucleoli In InterphaseColocalized With Chromosomes In MitosisWith A Gradually Increased During G1 Progression And A Maximum Level During Late G1 Phase (G1/S) |
| Alternative Antibody Names | Anti-Heterochromatin Protein 1-Binding Protein 3 antibodyAnti-Protein Hp1-Bp74 antibodyAnti-HP1BP3 antibody |
Information sourced from Uniprot.org