| Post Translational Modifications | Phosphorylation by AMPK reduces its translocation towards the lipid droplets. |
| Function | Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and of the fatty acid (FA) esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs. Preferentially hydrolyzes FA esters at the sn-3 position of the glycerol backbone in DAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. |
| Protein Name | Hormone-Sensitive LipaseHslMonoacylglycerol Lipase LipeRetinyl Ester HydrolaseReh |
| Database Links | |
| Cellular Localisation | Cell MembraneMembraneCaveolaCytoplasmCytosolLipid DropletFound In The High-Density CaveolaeTranslocates To The Cytoplasm From The Caveolae Upon Insulin StimulationPhosphorylation By Ampk Reduces Its Translocation Towards The Lipid Droplets |
| Alternative Antibody Names | Anti-Hormone-Sensitive Lipase antibodyAnti-Hsl antibodyAnti-Monoacylglycerol Lipase Lipe antibodyAnti-Retinyl Ester Hydrolase antibodyAnti-Reh antibodyAnti-Lipe antibody |
Information sourced from Uniprot.org
