| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Homer Protein Homolog 1 (101-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4194RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HOMER1 |
| Gene ID: |
9456 |
| Uniprot ID: |
HOME1_HUMAN |
| Immunogen Region: |
101-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 101-220 of human HOMER1 (NP_004263.1). |
| Immunogen Sequence: |
RLAKEKSQEKMELTSTPSQE SAGGDLQSPLTPESINGTDD ERTPDVTQNSEPRAEPTQNA LPFSHSSAISKHWEAELATL KGNNAKLTAALLESTANVKQ WKQQLAAYQE |
| Function | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA. |
| Protein Name | Homer Protein Homolog 1Homer-1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmPostsynaptic DensitySynapseCell ProjectionDendritic SpineIsoform 1 Inhibits Surface Expression Of Grm5 Causing It To Be Retained In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Homer Protein Homolog 1 antibodyAnti-Homer-1 antibodyAnti-HOMER1 antibodyAnti-SYN47 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
