| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-hnRNP E1/PCBP1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S7MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PCBP1 |
| Gene ID: |
5093 |
| Uniprot ID: |
PCBP1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PCBP1 (Q15365). |
| Immunogen Sequence: |
MDAGVTESGLNVTLTIRLLM HGKEVGSIIGKKGESVKRIR EESGARINISEGNCPERIIT LTGPTNAIFKAFAMIIDKLE EDINSSMTNSTAASRPPVTL |
| Tissue Specificity | Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. |
| Post Translational Modifications | Phosphorylated.lowers poly(rC)-binding activity. |
| Function | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing. (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. |
| Protein Name | Poly(Rc-Binding Protein 1Alpha-Cp1Heterogeneous Nuclear Ribonucleoprotein E1Hnrnp E1Nucleic Acid-Binding Protein Sub2.3 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203 |
| Cellular Localisation | NucleusCytoplasmLoosely Bound In The NucleusMay Shuttle Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Poly(Rc-Binding Protein 1 antibodyAnti-Alpha-Cp1 antibodyAnti-Heterogeneous Nuclear Ribonucleoprotein E1 antibodyAnti-Hnrnp E1 antibodyAnti-Nucleic Acid-Binding Protein Sub2.3 antibodyAnti-PCBP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
