| Post Translational Modifications | Ubiquitinated in s SPOP-dependent manner.leading to prteasomal degradation. |
| Function | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). |
| Protein Name | Hepatocyte Nuclear Factor 1-AlphaHnf-1-AlphaHnf-1aLiver-Specific Transcription Factor Lf-B1Lfb1Transcription Factor 1Tcf-1 |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Hepatocyte Nuclear Factor 1-Alpha antibodyAnti-Hnf-1-Alpha antibodyAnti-Hnf-1a antibodyAnti-Liver-Specific Transcription Factor Lf-B1 antibodyAnti-Lfb1 antibodyAnti-Transcription Factor 1 antibodyAnti-Tcf-1 antibodyAnti-HNF1A antibodyAnti-TCF1 antibody |
Information sourced from Uniprot.org
