| Short Description : | Rabbit monoclonal HNF-6/ONECUT1 (167-292 aa) antibody for use in IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM5414 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | IHC-P:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ONECUT1 |
| Gene ID: | 3175 |
| Uniprot ID: | HNF6_HUMAN |
| Immunogen Region: | 167-292 aa |
| Immunogen Sequence: | PYHKDVAGMGQSLSPLSSSG LGSIHNSQQGLPHYAHPGAA MPTDKMLTPNGFEAHHPAML GRHGEQHLTPTSAGMVPING LPPHHPHAHLNAQGHGQLLG TAREPNPSVTGAQVSNGSNS GQMEEI |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 167-292 of human HNF-6/ONECUT1 (NP_004489.1). |
| Tissue Specificity | Highly expressed in liver.lower expression in testis and skin. |
| Function | Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. |
| Protein Name | Hepatocyte Nuclear Factor 6Hnf-6One Cut Domain Family Member 1One Cut Homeobox 1 |
| Database Links | Reactome: R-HSA-210744Reactome: R-HSA-210747Reactome: R-HSA-9925561 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Hepatocyte Nuclear Factor 6 antibodyAnti-Hnf-6 antibodyAnti-One Cut Domain Family Member 1 antibodyAnti-One Cut Homeobox 1 antibodyAnti-ONECUT1 antibodyAnti-HNF6 antibodyAnti-HNF6A antibody |
Information sourced from Uniprot.org
