| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HMOX2 |
| Gene ID: | 3163 |
| Uniprot ID: | HMOX2_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human HMOX2 (NP_002125.3). |
| Immunogen Sequence: | MSAEVETSEGVDESEKKNSG ALEKENQMRMADLSELLKEG TKEAHDRAENTQFVKDFLKG NIKKELFKLATTALYFTYSA LEEEMERNKDHPAFAPLYFP MELHRKEALTKDMEYFFGEN WEEQVQCPKAAQKYVERIHY IGQNEPELLVAHAYTRYMGD LSGGQVLKKVAQRALKLPST GEGTQFYLFENVDNAQQFKQ LYRARMNALDLNMKTKERIV EEANKAFEYNMQIFNELDQ |
| Post Translational Modifications | A soluble form arises by proteolytic removal of the membrane anchor. S-nitrosylated by BLVRB. |
| Function | Heme oxygenase 2: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Heme oxygenase 2 soluble form: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. |
| Protein Name | Heme Oxygenase 2Ho-2 Cleaved Into - Heme Oxygenase 2 Soluble Form |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-6798695Reactome: R-HSA-8980692Reactome: R-HSA-917937Reactome: R-HSA-9707564 |
| Cellular Localisation | Microsome MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic SideEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Heme Oxygenase 2 antibodyAnti-Ho-2 Cleaved Into - Heme Oxygenase 2 Soluble Form antibodyAnti-HMOX2 antibodyAnti-HO2 antibody |
Information sourced from Uniprot.org