| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HMGCS1 |
| Gene ID: | 3157 |
| Uniprot ID: | HMCS1_HUMAN |
| Immunogen Region: | 241-520 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 241-520 of human HMGCS1 (NP_002121.4). |
| Immunogen Sequence: | HAQWQKEGNDKDFTLNDFGF MIFHSPYCKLVQKSLARMLL NDFLNDQNRDKNSIYSGLEA FGDVKLEDTYFDRDVEKAFM KASSELFSQKTKASLLVSNQ NGNMYTSSVYGSLASVLAQY SPQQLAGKRIGVFSYGSGLA ATLYSLKVTQDATPGSALDK ITASLCDLKSRLDSRTGVAP DVFAENMKLREDTHHLVNYI PQGSIDSLFEGTWYLVRVDE KHRRTYARRPTPNDDTLDE |
| Function | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. |
| Protein Name | Hydroxymethylglutaryl-Coa Synthase - CytoplasmicHmg-Coa Synthase3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-1989781Reactome: R-HSA-2426168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Hydroxymethylglutaryl-Coa Synthase - Cytoplasmic antibodyAnti-Hmg-Coa Synthase antibodyAnti-3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase antibodyAnti-HMGCS1 antibodyAnti-HMGCS antibody |
Information sourced from Uniprot.org